PDBe 3tso

X-ray diffraction
1.8Å resolution

Structure of the cancer associated Rab25 protein in complex with FIP2

Released:
Source organism: Homo sapiens
Entry authors: Oda S, Lall PY, McCaffrey MW, Khan AR

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ras-related protein Rab-25 Chains: A, B
Molecule details ›
Chains: A, B
Length: 178 amino acids
Theoretical weight: 19.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P57735 (Residues: 7-180; Coverage: 82%)
Gene names: CATX8, RAB25
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Rab11 family-interacting protein 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 75 amino acids
Theoretical weight: 8.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7L804 (Residues: 440-512; Coverage: 14%)
Gene names: KIAA0941, RAB11FIP2
Sequence domains: FIP domain

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P1
Unit cell:
a: 43.31Å b: 64.21Å c: 65.94Å
α: 113.25° β: 107.24° γ: 99.46°
R-values:
R R work R free
0.201 0.199 0.249
Expression system: Escherichia coli