3tsi

X-ray diffraction
2.65Å resolution

Structure of the parainfluenza virus 5 (PIV5) hemagglutinin-neuraminidase (HN) stalk domain

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemagglutinin-neuraminidase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 65 amino acids
Theoretical weight: 6.85 KDa
Source organism: Simian virus 5 (strain W3)
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P04850 (Residues: 56-117; Coverage: 11%)
Gene name: HN
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Spacegroup: P3221
Unit cell:
a: 101.276Å b: 101.276Å c: 85.713Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.204 0.202 0.238
Expression system: Trichoplusia ni