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Crystal structure of a multidomain human p53 tetramer bound to the natural CDKN1A(p21) p53-response element

X-ray diffraction
2.8Å resolution
PDB entry 3ts8 coloured by chain, front view.
PDB entry 3ts8 coloured by chain, side view.
PDB entry 3ts8 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero hexamer (preferred)
Entry contents: 1 distinct polypeptide molecule
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cellular tumor antigen p53 and DNA
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Multimeric state: hetero hexamer
Accessible surface area: 54021.82 Å2
Buried surface area: 14818.67 Å2
Dissociation area: 2,026.93 Å2
Dissociation energy (ΔGdiss): 12.45 kcal/mol
Dissociation entropy (TΔSdiss): 13.33 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-116943

Macromolecules

Cellular tumor antigen p53
Chains: A, B, C, D
Length: 234 amino acids
Theoretical weight: 26.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04637 (Residues: 94-356; Coverage: 60%)
Gene names: P53, TP53
Pfam:
InterPro:
CATH: Immunoglobulin-like
Cellular tumor antigen p53 in PDB entry 3ts8, assembly 1, front view.
Cellular tumor antigen p53 in PDB entry 3ts8, assembly 1, side view.
Cellular tumor antigen p53 in PDB entry 3ts8, assembly 1, top view.
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DNA chain K
Name: CDKN1A(p21) sense strand
Representative chains: K
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 26 nucleotides
Theoretical weight: 8.03 KDa
CDKN1A(p21) sense strand in PDB entry 3ts8, assembly 1, front view.
CDKN1A(p21) sense strand in PDB entry 3ts8, assembly 1, side view.
CDKN1A(p21) sense strand in PDB entry 3ts8, assembly 1, top view.
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DNA chain L
Name: CDKN1A(p21) anti-sense strand
Representative chains: L
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 26 nucleotides
Theoretical weight: 7.94 KDa
CDKN1A(p21) anti-sense strand in PDB entry 3ts8, assembly 1, front view.
CDKN1A(p21) anti-sense strand in PDB entry 3ts8, assembly 1, side view.
CDKN1A(p21) anti-sense strand in PDB entry 3ts8, assembly 1, top view.
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