› 3toj

X-ray diffraction
2.07Å resolution

Structure of the SPRY domain of human Ash2L

Released:
DOI: 10.2210/pdb3toj/pdb
PDB entry 3toj coloured by chain, front view.
PDB entry 3toj coloured by chain, side view.
PDB entry 3toj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the SPRY domain of human Ash2L and its interactions with RbBP5 and DPY30.
Chen Y, Cao F, Wan B, Dou Y, Lei M
Cell Res 22 598-602 (2012)
PMID: 22231628

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193656 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Set1/Ash2 histone methyltransferase complex subunit ASH2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 213 amino acids
Theoretical weight: 23.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UBL3 (Residues: 370-496, 516-617; Coverage: 33%)
Gene names: ASH2L, ASH2L1
Sequence domains: SPRY domain
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P3121
Unit cell:
a: 115.289Å b: 115.289Å c: 105.78Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.176 0.206
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Hijacked in cancer: the KMT2 (MLL) family of methyltransferases.
Rao et al. (2015)
7 more

10 mentions without citation

Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution.
Yan et al. (2015)
9 more