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Human MOF E350Q crystal structure with active site lysine partially acetylated

Source organism: Homo sapiens
Biochemical function: histone acetyltransferase activity
Biological process: regulation of DNA-templated transcription
Cellular component: not assigned

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EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF01853
Domain description: MOZ/SAS family
Occurring in:
  1. Histone acetyltransferase KAT8
The deposited structure of PDB entry 3tob contains 1 copy of Pfam domain PF01853 (MOZ/SAS family) in Histone acetyltransferase KAT8. Showing 1 copy in chain A.

PF17772
Domain description: MYST family zinc finger domain
Occurring in:
  1. Histone acetyltransferase KAT8
The deposited structure of PDB entry 3tob contains 1 copy of Pfam domain PF17772 (MYST family zinc finger domain) in Histone acetyltransferase KAT8. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002717
Domain description: Histone acetyltransferase domain, MYST-type
Occurring in:
  1. Histone acetyltransferase KAT8
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. Histone acetyltransferase KAT8
IPR040706
Domain description: MYST, zinc finger domain
Occurring in:
  1. Histone acetyltransferase KAT8
IPR016181
Domain description: Acyl-CoA N-acyltransferase
Occurring in:
  1. Histone acetyltransferase KAT8

Structure domains

CATH CATH domains
3.40.630.30
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aminopeptidase
Homology: Aminopeptidase
Occurring in:
  1. Histone acetyltransferase KAT8
The deposited structure of PDB entry 3tob contains 1 copy of CATH domain 3.40.630.30 (Aminopeptidase) in Histone acetyltransferase KAT8. Showing 1 copy in chain A.
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. Histone acetyltransferase KAT8
The deposited structure of PDB entry 3tob contains 1 copy of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in Histone acetyltransferase KAT8. Showing 1 copy in chain A.
3.30.60.60
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Wheat Germ Agglutinin (Isolectin 2); domain 1
Homology: N-acetyl transferase-like
Occurring in:
  1. Histone acetyltransferase KAT8
The deposited structure of PDB entry 3tob contains 1 copy of CATH domain 3.30.60.60 (Wheat Germ Agglutinin (Isolectin 2); domain 1) in Histone acetyltransferase KAT8. Showing 1 copy in chain A.

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