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Structure of the SHP-2 N-SH2 domain in a 1:2 complex with RVIpYFVPLNR peptide

X-ray diffraction
1.8Å resolution
PDB entry 3tkz coloured by chain, front view.
PDB entry 3tkz coloured by chain, side view.
PDB entry 3tkz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 11 and peptide
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Multimeric state: hetero trimer
Accessible surface area: 5704.8 Å2
Buried surface area: 2130.45 Å2
Dissociation area: 632.41 Å2
Dissociation energy (ΔGdiss): 8.59 kcal/mol
Dissociation entropy (TΔSdiss): 6.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-164078

Macromolecules

Tyrosine-protein phosphatase non-receptor type 11
Chain: A
Length: 109 amino acids
Theoretical weight: 12.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q06124 (Residues: 1-106; Coverage: 18%)
Gene names: PTP2C, PTPN11, SHPTP2
Pfam: SH2 domain
InterPro:
CATH: SH2 domain
Tyrosine-protein phosphatase non-receptor type 11 in PDB entry 3tkz, assembly 1, front view.
Tyrosine-protein phosphatase non-receptor type 11 in PDB entry 3tkz, assembly 1, side view.
Tyrosine-protein phosphatase non-receptor type 11 in PDB entry 3tkz, assembly 1, top view.
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PROTEIN (RVIpYFVPLNR peptide)
Chains: P, Q
Length: 10 amino acids
Theoretical weight: 1.36 KDa
Source organism: Homo sapiens
Expression system: Not provided
PROTEIN (RVIpYFVPLNR peptide) in PDB entry 3tkz, assembly 1, front view.
PROTEIN (RVIpYFVPLNR peptide) in PDB entry 3tkz, assembly 1, side view.
PROTEIN (RVIpYFVPLNR peptide) in PDB entry 3tkz, assembly 1, top view.
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