X-ray diffraction
2.07Å resolution

Crystal structure of dehydrosqualene synthase (crtm) from s. aureus complexed with bph-1183


Function and Biology Details

Reaction catalysed:
(1a) 2 (2E,6E)-farnesyl diphosphate = diphosphate + presqualene diphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
4,4'-diapophytoene synthase Chain: A
Molecule details ›
Chain: A
Length: 293 amino acids
Theoretical weight: 34.79 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli BL21
  • Canonical: A9JQL9 (Residues: 1-287; Coverage: 100%)
Gene name: crtM
Sequence domains: Squalene/phytoene synthase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P3221
Unit cell:
a: 80.229Å b: 80.229Å c: 91.82Å
α: 90° β: 90° γ: 120°
R R work R free
0.189 0.187 0.223
Expression system: Escherichia coli BL21