3tdk

X-ray diffraction
2.8Å resolution

Crystal Structure of Human UDP-Glucose Dehydrogenase

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UDP-glucose 6-dehydrogenase Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 487 amino acids
Theoretical weight: 54.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60701 (Residues: 1-487; Coverage: 99%)
Gene name: UGDH
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAD 12 x NAD
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P212121
Unit cell:
a: 173.132Å b: 191.177Å c: 225.807Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.23 0.261
Expression system: Escherichia coli