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Mouse RIG-I ATPase Domain

Source organism: Mus musculus
Biochemical function: ATP binding
Biological process: not assigned
Cellular component: not assigned

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EC 3.6.4.13: RNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
  • CSFV NS3 helicase
  • DBP2
  • DDX17
  • DDX25
  • DDX3
  • DDX3X
  • DDX3Y
  • DDX4
  • DDX5
  • DEAD-box RNA helicase
  • DEAD-box protein DED1
  • DEAH-box RNA helicase
  • DEAH-box protein 2
  • DED1
  • DbpA
  • Dex(H/D) RNA helicase
  • EIF4A helicase
  • EhDEAD1
  • EhDEAD1 RNA helicase
  • GRTH/DDX25
  • KOKV helicase
  • Mtr4p
  • NPH-II
  • Nonstructural protein 3 helicase
  • RHA
  • RNA helicase A
  • RNA helicase DDX3
  • RNA helicase Hera
  • RNA-dependent ATPase
  • TGBp1 NTPase/helicase domain
  • VRH1

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF00271
Domain description: Helicase conserved C-terminal domain
Occurring in:
  1. Antiviral innate immune response receptor RIG-I
The deposited structure of PDB entry 3tbk contains 1 copy of Pfam domain PF00271 (Helicase conserved C-terminal domain) in Antiviral innate immune response receptor RIG-I. Showing 1 copy in chain A.

PF18119
Domain description: RIG-I receptor C-terminal domain
Occurring in:
  1. Antiviral innate immune response receptor RIG-I
The deposited structure of PDB entry 3tbk contains 1 copy of Pfam domain PF18119 (RIG-I receptor C-terminal domain) in Antiviral innate immune response receptor RIG-I. Showing 1 copy in chain A.

PF00270
Domain description: DEAD/DEAH box helicase
Occurring in:
  1. Antiviral innate immune response receptor RIG-I

InterPro InterPro annotations
IPR001650
Domain description: Helicase, C-terminal domain-like
Occurring in:
  1. Antiviral innate immune response receptor RIG-I
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. Antiviral innate immune response receptor RIG-I
IPR014001
Domain description: Helicase superfamily 1/2, ATP-binding domain
Occurring in:
  1. Antiviral innate immune response receptor RIG-I
IPR041204
Domain description: RIG-I-like receptor, C-terminal
Occurring in:
  1. Antiviral innate immune response receptor RIG-I
IPR006935
Domain description: Helicase/UvrB, N-terminal
Occurring in:
  1. Antiviral innate immune response receptor RIG-I

Structure domains

CATH CATH domains
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. Antiviral innate immune response receptor RIG-I
The deposited structure of PDB entry 3tbk contains 2 copies of CATH domain 3.40.50.300 (Rossmann fold) in Antiviral innate immune response receptor RIG-I. Showing 2 copies in chain A.
1.20.1320.30
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: phosphoenolpyruvate carboxylase, domain 3
Homology: phosphoenolpyruvate carboxylase, domain 3
Occurring in:
  1. Antiviral innate immune response receptor RIG-I
The deposited structure of PDB entry 3tbk contains 1 copy of CATH domain 1.20.1320.30 (phosphoenolpyruvate carboxylase, domain 3) in Antiviral innate immune response receptor RIG-I. Showing 1 copy in chain A.

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