› 3t6q

X-ray diffraction
1.9Å resolution

Crystal structure of mouse RP105/MD-1 complex

Released:
DOI: 10.2210/pdb3t6q/pdb
PDB entry 3t6q coloured by chain, front view.
PDB entry 3t6q coloured by chain, side view.
PDB entry 3t6q coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family.
Ohto U, Miyake K, Shimizu T
J Mol Biol 413 815-25 (2011)
PMID: 21959264

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131529 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (5 distinct):
CD180 antigen Chains: A, B
Molecule details ›
Chains: A, B
Length: 606 amino acids
Theoretical weight: 67.99 KDa
Source organism: Mus musculus
Expression system: Drosophila
UniProt:
  • Canonical: Q62192 (Residues: 21-626; Coverage: 95%)
Gene names: Cd180, Ly78, Rp105
Sequence domains:
Lymphocyte antigen 86 Chains: C, D
Molecule details ›
Chains: C, D
Length: 145 amino acids
Theoretical weight: 16.2 KDa
Source organism: Mus musculus
Expression system: Drosophila
UniProt:
  • Canonical: O88188 (Residues: 20-162; Coverage: 100%)
Gene names: Ly86, Md1
Sequence domains: ML domain
Structure domains: Immunoglobulin-like

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Carbohydrate polymer
3 bound ligands:
Ligand CU 1 x CU
Ligand GOL 15 x GOL
Ligand NAG 13 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P21212
Unit cell:
a: 143.753Å b: 192.79Å c: 75.799Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.188 0.186 0.231
Expression system: Drosophila

Quick links

Citations

8 review citations

Sensing of microbial molecular patterns by Toll-like receptors.
Song et al. (2012)
7 more

2 mentions without citation

Broad Analysis of Vicinal Disulfides: Occurrences, Conformations with Cis or with Trans Peptides, and Functional Roles Including Sugar Binding.
Richardson et al. (2017)
1 more