3t6a

X-ray diffraction
2.4Å resolution

Structure of the C-terminal domain of BCAR3

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Breast cancer anti-estrogen resistance protein 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 333 amino acids
Theoretical weight: 38.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75815 (Residues: 502-825; Coverage: 39%)
Gene names: BCAR3, NSP2, SH2D3B, UNQ271/PRO308
Sequence domains: RasGEF domain
Structure domains: Ras guanine-nucleotide exchange factors catalytic domain

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 50.233Å b: 151.889Å c: 196.503Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.177 0.174 0.244
Expression system: Escherichia coli