X-ray diffraction
2.6Å resolution

Structure of human MICROCEPHALIN (MCPH1) TANDEM BRCT domains in complex with a CDC27 phosphopeptide


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Microcephalin Chains: A, B
Molecule details ›
Chains: A, B
Length: 199 amino acids
Theoretical weight: 21.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q8NEM0 (Residues: 640-835; Coverage: 24%)
Gene name: MCPH1
Sequence domains: BRCT domain, a BRCA1 C-terminus domain
Structure domains: BRCT domain
Cell division cycle protein 27 homolog Chains: C, D
Molecule details ›
Chains: C, D
Length: 4 amino acids
Theoretical weight: 576 Da
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P30260 (Residues: 821-824; Coverage: 1%)
Gene names: ANAPC3, CDC27, D0S1430E, D17S978E

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P1
Unit cell:
a: 38.201Å b: 46.506Å c: 55.322Å
α: 86.06° β: 70.69° γ: 89.67°
R R work R free
0.232 0.231 0.262
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided