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Crystal structure of 2-dehydro-3-deoxyphosphooctonate aldolase from Burkholderia pseudomallei

Source organism: Burkholderia pseudomallei 1710b
Biochemical function: transferase activity
Biological process: keto-3-deoxy-D-manno-octulosonic acid biosynthetic process
Cellular component: cytosol

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EC 2.5.1.55: 3-deoxy-8-phosphooctulonate synthase

Reaction catalysed:
Phosphoenolpyruvate + D-arabinose 5-phosphate + H(2)O = 3-deoxy-D-manno-octulosonate 8-phosphate + phosphate
Systematic name:
Phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolyzing, 2-carboxy-2-oxoethyl-forming)
Alternative Name(s):
  • 2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating)
  • 2-dehydro-3-deoxy-phosphooctonate aldolase
  • 2-keto-3-deoxy-8-phosphooctonic synthetase
  • 3-deoxy-D-manno-octulosonate-8-phosphate synthase
  • 3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase
  • 3-deoxy-D-mannooctulosonate-8-phosphate synthetase
  • 3-deoxyoctulosonic 8-phosphate synthetase
  • KDO-8-P synthase
  • KDO-8-phosphate synthetase
  • KDOP synthase
  • Phospho-2-keto-3-deoxyoctonate aldolase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00793
Domain description: DAHP synthetase I family
Occurring in:
  1. 2-dehydro-3-deoxyphosphooctonate aldolase
The deposited structure of PDB entry 3sz8 contains 4 copies of Pfam domain PF00793 (DAHP synthetase I family) in 2-dehydro-3-deoxyphosphooctonate aldolase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006269
Domain description: 3-deoxy-8-phosphooctulonate synthase
Occurring in:
  1. 2-dehydro-3-deoxyphosphooctonate aldolase
IPR006218
Domain description: DAHP synthetase I/KDSA
Occurring in:
  1. 2-dehydro-3-deoxyphosphooctonate aldolase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. 2-dehydro-3-deoxyphosphooctonate aldolase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. 2-dehydro-3-deoxyphosphooctonate aldolase
The deposited structure of PDB entry 3sz8 contains 4 copies of CATH domain 3.20.20.70 (TIM Barrel) in 2-dehydro-3-deoxyphosphooctonate aldolase. Showing 1 copy in chain A.

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