X-ray diffraction
2.98Å resolution

Crystal structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with sodium and PIP2


Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
G protein-activated inward rectifier potassium channel 2 Chain: A
Molecule details ›
Chain: A
Length: 340 amino acids
Theoretical weight: 39.06 KDa
Source organism: Mus musculus
Expression system: Komagataella pastoris
  • Canonical: P48542 (Residues: 52-380; Coverage: 77%)
  • Best match: P48542-3 (Residues: 52-318)
Gene names: Girk2, Kcnj6, Kcnj7, W
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P4212
Unit cell:
a: 85.851Å b: 85.851Å c: 177.862Å
α: 90° β: 90° γ: 90°
R R work R free
0.242 0.24 0.269
Expression system: Komagataella pastoris