Structure analysis

GLP (G9a-like protein) SET domain in complex with Dnmt3aK44me0 peptide

X-ray diffraction
3.05Å resolution
Source organisms:
Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer

Binding statistics and energies are not available for this assembly
Assembly 2
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Multimeric state: hetero dimer
Accessible surface area: 12900 Å2
Buried surface area: 2200 Å2
Dissociation area: 400 Å2
Dissociation energy (ΔGdiss): -11 kcal/mol
Dissociation entropy (TΔSdiss): 8 kcal/mol
Interface energy (ΔGint): -38 kcal/mol
Symmetry number: 1
Assembly 3
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Multimeric state: hetero tetramer
Accessible surface area: 24000 Å2
Buried surface area: 6300 Å2
Dissociation area: 800 Å2
Dissociation energy (ΔGdiss): -22 kcal/mol
Dissociation entropy (TΔSdiss): 16 kcal/mol
Interface energy (ΔGint): -85 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B
Length: 285 amino acids
Theoretical weight: 32.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H9B1 (Residues: 982-1266; Coverage: 22%)
Gene names: EHMT1, EUHMTASE1, GLP, KIAA1876, KMT1D
Pfam:
InterPro:
CATH: SET domain

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Chains: P, Q
Length: 12 amino acids
Theoretical weight: 1.26 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: O88508 (Residues: 39-50; Coverage: 1%)
Gene name: Dnmt3a

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