› 3sw0

X-ray diffraction
1.8Å resolution

Structure of the C-terminal region (modules 18-20) of complement regulator Factor H

Released:
DOI: 10.2210/pdb3sw0/pdb
PDB entry 3sw0 coloured by chain, front view.
PDB entry 3sw0 coloured by chain, side view.
PDB entry 3sw0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH).
Morgan HP, Mertens HD, Guariento M, Schmidt CQ, Soares DC, Svergun DI, Herbert AP, Barlow PN, Hannan JP
PLoS One 7 e32187 (2012)
PMID: 22389686

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor H Chain: X
Molecule details ›
Chain: X
Length: 188 amino acids
Theoretical weight: 21.42 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P08603 (Residues: 1046-1231; Coverage: 15%)
Gene names: CFH, HF, HF1, HF2
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

2 bound ligands:
Ligand GOL 4 x GOL
Ligand PO4 1 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Unit cell:
a: 45.97Å b: 68.6Å c: 77.48Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.226
Expression system: Komagataella pastoris

Quick links

Citations

5 review citations

Complement System Part I - Molecular Mechanisms of Activation and Regulation.
Merle et al. (2015)
4 more

12 mentions without citation

Putting the structure into complement.
Lea et al. (2012)
11 more