› 3sto

X-ray diffraction
2.41Å resolution

Serpin from the trematode Schistosoma Haematobium

Released:
DOI: 10.2210/pdb3sto/pdb
PDB 3sto coloured by chain and viewed from the front.
PDB 3sto coloured by chain and viewed from the side.
PDB 3sto coloured by chain and viewed from the top.
Source organism: Schistosoma haematobium
Primary publication:
Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain.
Granzin J, Huang Y, Topbas C, Huang W, Wu Z, Misra S, Hazen SL, Blanton RE, Lee X, Weiergr��ber OH
Acta Crystallogr. D Biol. Crystallogr. 68 686-94 (2012)
PMID: 22683791

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serpin domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 406 amino acids
Theoretical weight: 46.35 KDa
Source organism: Schistosoma haematobium
Expression system: Escherichia coli
UniProt:
  • Canonical: Q26502 (Residues: 1-406; Coverage: 100%)
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 10 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P3221
Unit cell:
a: 64.913Å b: 64.913Å c: 187.004Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.165 0.162 0.213
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Protease Inhibitors of Parasitic Flukes: Emerging Roles in Parasite Survival and Immune Defence.
Ranasinghe et al. (2017)
2 other articles

4 mentions without citation

A Comprehensive Phylogenetic Analysis of the Serpin Superfamily.
Spence et al. (2021)
3 more