› 3ss6

X-ray diffraction
1.7Å resolution

Crystal structure of the Bacillus anthracis acetyl-CoA acetyltransferase

Released:
DOI: 10.2210/pdb3ss6/pdb
PDB entry 3ss6 coloured by chain, front view.
PDB entry 3ss6 coloured by chain, side view.
PDB entry 3ss6 coloured by chain, top view.
Source organism: Bacillus anthracis str. 'Ames Ancestor'
Entry authors: Anderson SM, Wawrzak Z, Onopriyenko O, Peterson SN, Anderson WF, Savchenko A, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Reaction catalysed: 
(1a) acetyl-CoA + [acetyl-CoA C-acetyltransferase]-L-cysteine = [acetyl-CoA C-acetyltransferase]-S-acetyl-L-cysteine + CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-105640 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acetyl-CoA acetyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 394 amino acids
Theoretical weight: 42.28 KDa
Source organism: Bacillus anthracis str. 'Ames Ancestor'
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A6H3AND8 (Residues: 1-391; Coverage: 100%)
Gene name: GBAA_4240
Sequence domains:
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

2 bound ligands:
Ligand SO4 7 x SO4
Ligand K 3 x K
1 modified residue:
Ligand CSO 2 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P3121
Unit cell:
a: 94.72Å b: 94.72Å c: 189.26Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.154 0.152 0.175
Expression system: Escherichia coli BL21(DE3)

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