X-ray diffraction
2.21Å resolution

Structure of human glutathione reductase complexed with pyocyanin, an agent with antimalarial activity

Source organism: Homo sapiens
Entry authors: Fritz-Wolf K, Schirmer RH, Koenig I, Goebel U

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Glutathione reductase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 478 amino acids
Theoretical weight: 51.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P00390 (Residues: 45-522; Coverage: 92%)
Gene names: GLUR, GRD1, GSR
Sequence domains:
Structure domains:

Ligands and Environments

Cofactor: Ligand FAD 2 x FAD
3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P1
Unit cell:
a: 62.08Å b: 67.37Å c: 78.86Å
α: 68.98° β: 66.81° γ: 62.54°
R R work R free
0.146 0.144 0.182
Expression system: Escherichia coli