PDBe 3sqd

X-ray diffraction
2.15Å resolution

Crystal structure of human PTIP BRCT5/6-gamma H2AX complex

Released:
Source organism: Homo sapiens
Entry authors: Yan W, Shao ZH

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PAX-interacting protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 219 amino acids
Theoretical weight: 25.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6ZW49 (Residues: 860-1069; Coverage: 20%)
Gene names: CAGF28, PAXIP1, PAXIP1L, PTIP
Sequence domains: BRCA1 C Terminus (BRCT) domain
Structure domains: BRCT domain
Histone H2AX Chains: C, D
Molecule details ›
Chains: C, D
Length: 10 amino acids
Theoretical weight: 1.24 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P16104 (Residues: 134-143; Coverage: 7%)
Gene names: H2AFX, H2AX

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21212
Unit cell:
a: 84.973Å b: 101.812Å c: 61.815Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.197 0.248
Expression systems:
  • Escherichia coli
  • Not provided