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Inward rectifier potassium channel Kir2.2 I223L mutant in complex with PIP2

X-ray diffraction
3.003Å resolution
PDB entry 3sph coloured by chain, front view.
PDB entry 3sph coloured by chain, side view.
PDB entry 3sph coloured by chain, top view.
Source organism: Gallus gallus
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: ATP-sensitive inward rectifier potassium channel 12
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Multimeric state: homo tetramer
Accessible surface area: 56581.8 Å2
Buried surface area: 30357.77 Å2
Dissociation area: 318.28 Å2
Dissociation energy (ΔGdiss): -4.34 kcal/mol
Dissociation entropy (TΔSdiss): 3.21 kcal/mol
Symmetry number: 4
PDBe Complex ID: PDB-CPX-123320

Macromolecules

ATP-sensitive inward rectifier potassium channel 12
Chain: A
Length: 343 amino acids
Theoretical weight: 39.36 KDa
Source organism: Gallus gallus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: F1NHE9 (Residues: 37-372; Coverage: 78%)
Gene name: KCNJ12
Pfam:
InterPro:
CATH:
ATP-sensitive inward rectifier potassium channel 12 in PDB entry 3sph, assembly 1, front view.
ATP-sensitive inward rectifier potassium channel 12 in PDB entry 3sph, assembly 1, side view.
ATP-sensitive inward rectifier potassium channel 12 in PDB entry 3sph, assembly 1, top view.
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