PDBe 3soq

X-ray diffraction
1.9Å resolution

The structure of the first YWTD beta propeller domain of LRP6 in complex with a DKK1 peptide

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Low-density lipoprotein receptor-related protein 6 Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 35.69 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75581 (Residues: 20-326; Coverage: 19%)
Gene name: LRP6
Sequence domains:
Structure domains:
Dickkopf-related protein 1 Chain: Z
Molecule details ›
Chain: Z
Length: 9 amino acids
Theoretical weight: 785 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O94907 (Residues: 38-44; Coverage: 3%)
Gene names: DKK1, UNQ492/PRO1008

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 103.32Å b: 46.976Å c: 68.722Å
α: 90° β: 97.27° γ: 90°
R-values:
R R work R free
0.179 0.177 0.221
Expression systems:
  • Spodoptera frugiperda
  • Not provided