› 3sj2

X-ray diffraction
1.36Å resolution

A Crystal Structure of a Model of the Repeating r(CGG) Transcript Found in Fragile X Syndrome

Released:
DOI: 10.2210/pdb3sj2/pdb
PDB 3sj2 coloured by chain and viewed from the front.
PDB 3sj2 coloured by chain and viewed from the side.
PDB 3sj2 coloured by chain and viewed from the top.
Source organism: Synthetic construct
Entry authors: Kumar A, Pengfei F, Park H, Nettles K, Guo M, Disney MD

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct RNA molecules
Macromolecules (2 distinct):
RNA (5'-R(*UP*UP*GP*GP*GP*CP*CP*GP*GP*CP*GP*GP*CP*GP*GP*GP*UP*CP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 19 nucleotides
Theoretical weight: 6.16 KDa
Source organism: Synthetic construct
Expression system: Not provided
RNA (5'-R(P*GP*GP*GP*CP*CP*GP*GP*CP*GP*GP*CP*GP*GP*GP*UP*CP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 17 nucleotides
Theoretical weight: 5.54 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ACT 2 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: C2
Unit cell:
a: 55.66Å b: 32.32Å c: 69.442Å
α: 90° β: 108.95° γ: 90°
R-values:
R R work R free
0.157 0.154 0.185
Expression system: Not provided

Quick links

Citations

5 review citations

Molecular conformations and dynamics of nucleotide repeats associated with neurodegenerative diseases: double helices and CAG hairpin loops.
Pan et al. (2021)
4 more

3 mentions without citation

RNA Structures as Mediators of Neurological Diseases and as Drug Targets.
Bernat et al. (2015)
2 more