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crystal structure of murine norovirus RNA dependent RNA polymerase in complex with ribavirin

X-ray diffraction
2.501Å resolution
PDB entry 3sfu coloured by chain, front view.
PDB entry 3sfu coloured by chain, side view.
PDB entry 3sfu coloured by chain, top view.
Source organism: Murine norovirus 1
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Viral genome-linked protein
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Multimeric state: homo dimer
Accessible surface area: 42898.33 Å2
Buried surface area: 9517.93 Å2
Dissociation area: 1,261.31 Å2
Dissociation energy (ΔGdiss): -1.22 kcal/mol
Dissociation entropy (TΔSdiss): 14.71 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-182355
Assembly 2 (preferred)
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Assembly Name: Viral genome-linked protein
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Multimeric state: homo dimer
Accessible surface area: 43137.07 Å2
Buried surface area: 8963.42 Å2
Dissociation area: 1,291.55 Å2
Dissociation energy (ΔGdiss): 7.36 kcal/mol
Dissociation entropy (TΔSdiss): 14.73 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-182355

Macromolecules

RNA-directed RNA polymerase
Chains: A, B, C
Length: 517 amino acids
Theoretical weight: 58.52 KDa
Source organism: Murine norovirus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q80J95 (Residues: 1181-1686; Coverage: 30%)
Gene name: ORF1
Pfam: Viral RNA-dependent RNA polymerase
InterPro:
CATH:
RNA polymerase in PDB entry 3sfu, assembly 2, front view.
RNA polymerase in PDB entry 3sfu, assembly 2, side view.
RNA polymerase in PDB entry 3sfu, assembly 2, top view.
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