PDBe 3se4

X-ray diffraction
3.5Å resolution

human IFNw-IFNAR ternary complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Interferon alpha/beta receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 414 amino acids
Theoretical weight: 47.63 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P17181 (Residues: 28-436; Coverage: 77%)
Gene names: IFNAR, IFNAR1
Sequence domains: Interferon-alpha/beta receptor, fibronectin type III
Structure domains: Immunoglobulins
Interferon omega-1 Chain: B
Molecule details ›
Chain: B
Length: 177 amino acids
Theoretical weight: 20.48 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P05000 (Residues: 22-195; Coverage: 100%)
Gene name: IFNW1
Sequence domains: Interferon alpha/beta domain
Structure domains: Growth Hormone; Chain: A;
Interferon alpha/beta receptor 2 Chain: C
Molecule details ›
Chain: C
Length: 199 amino acids
Theoretical weight: 22.89 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P48551 (Residues: 34-232; Coverage: 41%)
Gene names: IFNABR, IFNAR2, IFNARB
Sequence domains: Interferon-alpha/beta receptor, fibronectin type III
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P6122
Unit cell:
a: 93.49Å b: 93.49Å c: 403.13Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.213 0.288
Expression systems:
  • Trichoplusia ni
  • Homo sapiens