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Complex between transferrin receptor 1 and transferrin with iron in the N-Lobe, room temperature

Source organism: Homo sapiens
Biochemical function: transferrin receptor binding
Biological process: positive regulation of cell motility
Cellular component: HFE-transferrin receptor complex

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00405
Domain description: Transferrin
Occurring in:
  1. Serotransferrin
The deposited structure of PDB entry 3s9n contains 4 copies of Pfam domain PF00405 (Transferrin) in Serotransferrin. Showing 2 copies in chain C.

PF04253
Domain description: Transferrin receptor-like dimerisation domain
Occurring in:
  1. Transferrin receptor protein 1, serum form
The deposited structure of PDB entry 3s9n contains 2 copies of Pfam domain PF04253 (Transferrin receptor-like dimerisation domain) in Transferrin receptor protein 1, serum form. Showing 1 copy in chain B.

PF04389
Domain description: Peptidase family M28
Occurring in:
  1. Transferrin receptor protein 1, serum form
The deposited structure of PDB entry 3s9n contains 2 copies of Pfam domain PF04389 (Peptidase family M28) in Transferrin receptor protein 1, serum form. Showing 1 copy in chain B.

PF02225
Domain description: PA domain
Occurring in:
  1. Transferrin receptor protein 1, serum form
The deposited structure of PDB entry 3s9n contains 2 copies of Pfam domain PF02225 (PA domain) in Transferrin receptor protein 1, serum form. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001156
Domain description: Transferrin-like domain
Occurring in:
  1. Serotransferrin
IPR018195
Domain description: Transferrin family, iron binding site
Occurring in:
  1. Serotransferrin
IPR036757
Domain description: Transferrin receptor-like, dimerisation domain superfamily
Occurring in:
  1. Transferrin receptor protein 1, serum form
IPR030685
Domain description: Serotransferrin, mammalian
Occurring in:
  1. Serotransferrin
IPR016357
Domain description: Transferrin
Occurring in:
  1. Serotransferrin
IPR007365
Domain description: Transferrin receptor-like, dimerisation domain
Occurring in:
  1. Transferrin receptor protein 1, serum form
IPR007484
Domain description: Peptidase M28
Occurring in:
  1. Transferrin receptor protein 1, serum form
IPR003137
Domain description: PA domain
Occurring in:
  1. Transferrin receptor protein 1, serum form
IPR037324
Domain description: Transferrin receptor protein 1/2, PA domain
Occurring in:
  1. Transferrin receptor protein 1, serum form
IPR046450
Domain description: PA domain superfamily
Occurring in:
  1. Transferrin receptor protein 1, serum form
IPR039373
Domain description: Transferrin receptor protein 1/Glutamate carboxypeptidase 2-like
Occurring in:
  1. Transferrin receptor protein 1, serum form

Structure domains

CATH CATH domains
3.40.190.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: D-Maltodextrin-Binding Protein; domain 2
Homology: Periplasmic binding protein-like II
Occurring in:
  1. Serotransferrin
The deposited structure of PDB entry 3s9n contains 6 copies of CATH domain 3.40.190.10 (D-Maltodextrin-Binding Protein; domain 2) in Serotransferrin. Showing 3 copies in chain C.
3.40.630.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aminopeptidase
Homology: Zn peptidases
Occurring in:
  1. Transferrin receptor protein 1, serum form
The deposited structure of PDB entry 3s9n contains 2 copies of CATH domain 3.40.630.10 (Aminopeptidase) in Transferrin receptor protein 1, serum form. Showing 1 copy in chain B.
1.20.930.40
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Transcription Elongation Factor S-II; Chain A
Homology: Transferrin receptor-like, dimerisation domain
Occurring in:
  1. Transferrin receptor protein 1, serum form
The deposited structure of PDB entry 3s9n contains 2 copies of CATH domain 1.20.930.40 (Transcription Elongation Factor S-II; Chain A) in Transferrin receptor protein 1, serum form. Showing 1 copy in chain B.
3.50.30.30
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: Glucose Oxidase; domain 1
Homology: Glucose Oxidase; domain 1
Occurring in:
  1. Transferrin receptor protein 1, serum form
The deposited structure of PDB entry 3s9n contains 2 copies of CATH domain 3.50.30.30 (Glucose Oxidase; domain 1) in Transferrin receptor protein 1, serum form. Showing 1 copy in chain B.

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