› 3s92

X-ray diffraction
1.36Å resolution

Crystal Structure of the second bromodomain of human BRD3 in complex with the inhibitor JQ1

Released:
DOI: 10.2210/pdb3s92/pdb
PDB entry 3s92 coloured by chain, front view.
PDB entry 3s92 coloured by chain, side view.
PDB entry 3s92 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Picaud S, Qi J, Keates T, Felletar I, Fedorov O, Muniz J, von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Bradner JE, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172178 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 3 Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 13.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15059 (Residues: 306-416; Coverage: 15%)
Gene names: BRD3, KIAA0043, RING3L
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

2 bound ligands:
Ligand JQ1 1 x JQ1
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P2221
Unit cell:
a: 33.36Å b: 38.02Å c: 85.79Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.134 0.131 0.186
Expression system: Escherichia coli

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