PDBe 3s8v

X-ray diffraction
3.1Å resolution

Crystal structure of LRP6-Dkk1 complex

Source organism: Homo sapiens
Primary publication:
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1.
Nat. Struct. Mol. Biol. 18 1204-10 (2011)
PMID: 21984209

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Low-density lipoprotein receptor-related protein 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 623 amino acids
Theoretical weight: 70.83 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: O75581 (Residues: 629-1243; Coverage: 39%)
Gene name: LRP6
Sequence domains:
Structure domains: TolB, C-terminal domain
Dickkopf-related protein 1 Chain: X
Molecule details ›
Chain: X
Length: 88 amino acids
Theoretical weight: 9.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: O94907 (Residues: 183-266; Coverage: 36%)
Gene names: DKK1, UNQ492/PRO1008
Structure domains: Lipase, subunit A

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2, ALS BEAMLINE 8.2.1
Spacegroup: P212121
Unit cell:
a: 94.384Å b: 105.05Å c: 161.226Å
α: 90° β: 90° γ: 90°
R R work R free
0.243 0.24 0.292
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli BL21