PDBe 3s8o

X-ray diffraction
1.85Å resolution

Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth factor receptor-bound protein 2 Chain: A
Molecule details ›
Chain: A
Length: 117 amino acids
Theoretical weight: 13.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Best match: P62993 (Residues: 53-163)
Gene names: ASH, GRB2
pYAc6cN Chain: B
Molecule details ›
Chain: B
Length: 5 amino acids
Theoretical weight: 524 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

2 bound ligands:

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P43212
Unit cell:
a: 42.154Å b: 42.154Å c: 109.513Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.153 0.15 0.201
Expression systems:
  • Escherichia coli
  • Not provided