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Crystal structure of human frataxin variant W155R, one of the Friedreich's ataxia point mutations

X-ray diffraction
1.31Å resolution
PDB entry 3s5e coloured by chain, front view.
PDB entry 3s5e coloured by chain, side view.
PDB entry 3s5e coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Frataxin mature form
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Multimeric state: monomeric
Accessible surface area: 6562.64 Å2
Buried surface area: 102.23 Å2
Dissociation area: 51.12 Å2
Dissociation energy (ΔGdiss): 9.75 kcal/mol
Dissociation entropy (TΔSdiss): -1.47 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172517

Macromolecules

Frataxin mature form
Chain: A
Length: 129 amino acids
Theoretical weight: 14.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16595 (Residues: 82-210; Coverage: 61%)
Gene names: FRDA, FXN, X25
Pfam: Frataxin-like domain
InterPro:
CATH: Frataxin/CyaY
Frataxin mature form in PDB entry 3s5e, assembly 1, front view.
Frataxin mature form in PDB entry 3s5e, assembly 1, side view.
Frataxin mature form in PDB entry 3s5e, assembly 1, top view.
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