3s2k

X-ray diffraction
2.8Å resolution

Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6.

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Low-density lipoprotein receptor-related protein 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 629 amino acids
Theoretical weight: 71.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O75581 (Residues: 630-1246; Coverage: 39%)
Gene name: LRP6
Sequence domains:
Structure domains: TolB, C-terminal domain
Dickkopf-related protein 1 Chain: C
Molecule details ›
Chain: C
Length: 97 amino acids
Theoretical weight: 11.11 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O94907 (Residues: 178-266; Coverage: 38%)
Gene names: DKK1, UNQ492/PRO1008
Structure domains: Lipase, subunit A

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P212121
Unit cell:
a: 96.043Å b: 108.014Å c: 173.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.194 0.251
Expression system: Spodoptera frugiperda