3rze

X-ray diffraction
3.1Å resolution

Structure of the human histamine H1 receptor in complex with doxepin

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endolysin; Histamine H1 receptor Chain: A
Molecule details ›
Chain: A
Length: 452 amino acids
Theoretical weight: 52.38 KDa
Source organisms: Expression system: Komagataella pastoris
UniProt:
  • Canonical: P35367 (Residues: 20-221, 377-377, 405-487; Coverage: 59%)
  • Canonical: P00720 (Residues: 2-136, 138-161; Coverage: 97%)
Gene names: E, HRH1
Sequence domains:
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: I422
Unit cell:
a: 88.144Å b: 88.144Å c: 331.654Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.214 0.249
Expression system: Komagataella pastoris