› 3rvy

X-ray diffraction
2.7Å resolution

Crystal structure of the NavAb voltage-gated sodium channel (Ile217Cys, 2.7 A)

Released:
DOI: 10.2210/pdb3rvy/pdb
PDB entry 3rvy coloured by chain, front view.
PDB entry 3rvy coloured by chain, side view.
PDB entry 3rvy coloured by chain, top view.
Source organism: Aliarcobacter butzleri RM4018
Primary publication:
The crystal structure of a voltage-gated sodium channel.
Payandeh J, Scheuer T, Zheng N, Catterall WA
Nature 475 353-8 (2011)
PMID: 21743477

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-108631 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 285 amino acids
Theoretical weight: 33.11 KDa
Source organism: Aliarcobacter butzleri RM4018
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A8EVM5 (Residues: 1-267; Coverage: 100%)
Gene name: Abu_1752
Sequence domains: Ion transport protein
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand PX4 10 x PX4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: I222
Unit cell:
a: 125.594Å b: 125.483Å c: 192.297Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.273 0.266 0.273
Expression system: Trichoplusia ni

Quick links

Citations

193 review citations

hERG K(+) channels: structure, function, and clinical significance.
Vandenberg et al. (2012)
192 more

112 mentions without citation

The hitchhiker's guide to the voltage-gated sodium channel galaxy.
Ahern et al. (2016)
111 more