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FXR with SRC1 and GSK237

X-ray diffraction
2.502Å resolution
PDB entry 3ruu coloured by chain, front view.
PDB entry 3ruu coloured by chain, side view.
PDB entry 3ruu coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Bile acid receptor and Nuclear receptor coactivator 1
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Multimeric state: hetero dimer
Accessible surface area: 11392.83 Å2
Buried surface area: 1268.26 Å2
Dissociation area: 496.89 Å2
Dissociation energy (ΔGdiss): 3.87 kcal/mol
Dissociation entropy (TΔSdiss): 7.25 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172398

Macromolecules

Bile acid receptor
Chain: A
Length: 229 amino acids
Theoretical weight: 26.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96RI1 (Residues: 258-486; Coverage: 47%)
Gene names: BAR, FXR, HRR1, NR1H4, RIP14
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
Bile acid receptor in PDB entry 3ruu, assembly 1, front view.
Bile acid receptor in PDB entry 3ruu, assembly 1, side view.
Bile acid receptor in PDB entry 3ruu, assembly 1, top view.
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Nuclear receptor coactivator 1
Chain: B
Length: 11 amino acids
Theoretical weight: 1.42 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 745-755; Coverage: 1%)
Gene names: BHLHE74, NCOA1, SRC1
Nuclear receptor coactivator 1 in PDB entry 3ruu, assembly 1, front view.
Nuclear receptor coactivator 1 in PDB entry 3ruu, assembly 1, side view.
Nuclear receptor coactivator 1 in PDB entry 3ruu, assembly 1, top view.
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