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Structural and biochemical characterization of two binding sites for nucleation promoting factor WASp-VCA on Arp2/3 complex

Source organism: Bos taurus
Biochemical function: actin filament binding
Biological process: Arp2/3 complex-mediated actin nucleation
Cellular component: Arp2/3 protein complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00022
Domain description: Actin
Occurring in:
  1. Actin-related protein 3
  2. Actin-related protein 2
The deposited structure of PDB entry 3rse contains 1 copy of Pfam domain PF00022 (Actin) in Actin-related protein 3. Showing 1 copy in chain A.
The deposited structure of PDB entry 3rse contains 1 copy of Pfam domain PF00022 (Actin) in Actin-related protein 2. Showing 1 copy in chain B.

PF00400
Domain description: WD domain, G-beta repeat
Occurring in:
  1. Actin-related protein 2/3 complex subunit 1B
The deposited structure of PDB entry 3rse contains 2 copies of Pfam domain PF00400 (WD domain, G-beta repeat) in Actin-related protein 2/3 complex subunit 1B. Showing 2 copies in chain C.

PF04699
Domain description: ARP2/3 complex 16 kDa subunit (p16-Arc)
Occurring in:
  1. Actin-related protein 2/3 complex subunit 5
The deposited structure of PDB entry 3rse contains 1 copy of Pfam domain PF04699 (ARP2/3 complex 16 kDa subunit (p16-Arc)) in Actin-related protein 2/3 complex subunit 5. Showing 1 copy in chain G.

PF05856
Domain description: ARP2/3 complex 20 kDa subunit (ARPC4)
Occurring in:
  1. Actin-related protein 2/3 complex subunit 4
The deposited structure of PDB entry 3rse contains 1 copy of Pfam domain PF05856 (ARP2/3 complex 20 kDa subunit (ARPC4)) in Actin-related protein 2/3 complex subunit 4. Showing 1 copy in chain F.

PF04062
Domain description: ARP2/3 complex ARPC3 (21 kDa) subunit
Occurring in:
  1. Actin-related protein 2/3 complex subunit 3
The deposited structure of PDB entry 3rse contains 1 copy of Pfam domain PF04062 (ARP2/3 complex ARPC3 (21 kDa) subunit) in Actin-related protein 2/3 complex subunit 3. Showing 1 copy in chain E.

PF04045
Domain description: Arp2/3 complex, 34 kD subunit p34-Arc
Occurring in:
  1. Actin-related protein 2/3 complex subunit 2
The deposited structure of PDB entry 3rse contains 1 copy of Pfam domain PF04045 (Arp2/3 complex, 34 kD subunit p34-Arc) in Actin-related protein 2/3 complex subunit 2. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR004000
Domain description: Actin family
Occurring in:
  1. Actin-related protein 3
  2. Actin-related protein 2
IPR001680
Domain description: WD40 repeat
Occurring in:
  1. Actin-related protein 2/3 complex subunit 1B
IPR034666
Domain description: Arp2/3 complex subunit 2/4
Occurring in:
  1. Actin-related protein 2/3 complex subunit 2
  2. Actin-related protein 2/3 complex subunit 4
IPR043129
Domain description: ATPase, nucleotide binding domain
Occurring in:
  1. Actin-related protein 3
  2. Actin-related protein 2
IPR006789
Domain description: Actin-related protein 2/3 complex subunit 5
Occurring in:
  1. Actin-related protein 2/3 complex subunit 5
IPR036743
Domain description: Actin-related protein 2/3 complex subunit 5 superfamily
Occurring in:
  1. Actin-related protein 2/3 complex subunit 5
IPR008384
Domain description: Actin-related protein 2/3 complex subunit 4
Occurring in:
  1. Actin-related protein 2/3 complex subunit 4
IPR036753
Domain description: Actin-related protein 2/3 complex subunit 3 superfamily
Occurring in:
  1. Actin-related protein 2/3 complex subunit 3
IPR007204
Domain description: Actin-related protein 2/3 complex subunit 3
Occurring in:
  1. Actin-related protein 2/3 complex subunit 3
IPR007188
Domain description: Actin-related protein 2/3 complex subunit 2
Occurring in:
  1. Actin-related protein 2/3 complex subunit 2
IPR017383
Domain description: Actin-related protein 2/3 complex subunit 1
Occurring in:
  1. Actin-related protein 2/3 complex subunit 1B
IPR020902
Domain description: Actin/actin-like conserved site
Occurring in:
  1. Actin-related protein 3
  2. Actin-related protein 2
IPR036322
Domain description: WD40-repeat-containing domain superfamily
Occurring in:
  1. Actin-related protein 2/3 complex subunit 1B
IPR015943
Domain description: WD40/YVTN repeat-like-containing domain superfamily
Occurring in:
  1. Actin-related protein 2/3 complex subunit 1B

Structure domains

CATH CATH domains
3.30.420.40
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Nucleotidyltransferase; domain 5
Occurring in:
  1. Actin-related protein 3
  2. Actin-related protein 2
The deposited structure of PDB entry 3rse contains 2 copies of CATH domain 3.30.420.40 (Nucleotidyltransferase; domain 5) in Actin-related protein 3. Showing 2 copies in chain A.
The deposited structure of PDB entry 3rse contains 1 copy of CATH domain 3.30.420.40 (Nucleotidyltransferase; domain 5) in Actin-related protein 2. Showing 1 copy in chain B.
3.30.1460.20
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Yope Regulator; Chain: A,
Homology: Yope Regulator; Chain: A,
Occurring in:
  1. Actin-related protein 2/3 complex subunit 2
  2. Actin-related protein 2/3 complex subunit 4
The deposited structure of PDB entry 3rse contains 2 copies of CATH domain 3.30.1460.20 (Yope Regulator; Chain: A,) in Actin-related protein 2/3 complex subunit 2. Showing 2 copies in chain D.
The deposited structure of PDB entry 3rse contains 1 copy of CATH domain 3.30.1460.20 (Yope Regulator; Chain: A,) in Actin-related protein 2/3 complex subunit 4. Showing 1 copy in chain F.
3.90.640.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Actin; Chain A, domain 4
Homology: Actin; Chain A, domain 4
Occurring in:
  1. Actin-related protein 3
  2. Actin-related protein 2
The deposited structure of PDB entry 3rse contains 1 copy of CATH domain 3.90.640.10 (Actin; Chain A, domain 4) in Actin-related protein 3. Showing 1 copy in chain A.
The deposited structure of PDB entry 3rse contains 1 copy of CATH domain 3.90.640.10 (Actin; Chain A, domain 4) in Actin-related protein 2. Showing 1 copy in chain B.
1.25.40.190
Class: Mainly Alpha
Architecture: Alpha Horseshoe
Topology: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homology: Actin-related protein 2/3 complex subunit 5
Occurring in:
  1. Actin-related protein 2/3 complex subunit 5
The deposited structure of PDB entry 3rse contains 1 copy of CATH domain 1.25.40.190 (Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat) in Actin-related protein 2/3 complex subunit 5. Showing 1 copy in chain G.
1.10.1760.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arp2/3 complex 21 kDa subunit ARPC3
Homology: Actin-related protein 2/3 complex subunit 3
Occurring in:
  1. Actin-related protein 2/3 complex subunit 3
The deposited structure of PDB entry 3rse contains 1 copy of CATH domain 1.10.1760.10 (Arp2/3 complex 21 kDa subunit ARPC3) in Actin-related protein 2/3 complex subunit 3. Showing 1 copy in chain E.
2.130.10.10
Class: Mainly Beta
Architecture: 7 Propeller
Topology: Methylamine Dehydrogenase; Chain H
Homology: YVTN repeat-like/Quinoprotein amine dehydrogenase
Occurring in:
  1. Actin-related protein 2/3 complex subunit 1B
The deposited structure of PDB entry 3rse contains 1 copy of CATH domain 2.130.10.10 (Methylamine Dehydrogenase; Chain H) in Actin-related protein 2/3 complex subunit 1B. Showing 1 copy in chain C.

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