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Domain-domain flexibility leads to allostery within the camp receptor protein (CRP)

Source organism: Escherichia coli K-12
Biochemical function: sequence-specific DNA binding
Biological process: positive regulation of DNA-templated transcription
Cellular component: protein-DNA complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF13545
Domain description: Crp-like helix-turn-helix domain
Occurring in:
  1. DNA-binding transcriptional dual regulator CRP
The deposited structure of PDB entry 3rpq contains 2 copies of Pfam domain PF13545 (Crp-like helix-turn-helix domain) in DNA-binding transcriptional dual regulator CRP. Showing 1 copy in chain B.

PF00027
Domain description: Cyclic nucleotide-binding domain
Occurring in:
  1. DNA-binding transcriptional dual regulator CRP
The deposited structure of PDB entry 3rpq contains 2 copies of Pfam domain PF00027 (Cyclic nucleotide-binding domain) in DNA-binding transcriptional dual regulator CRP. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR012318
Domain description: Crp-type HTH domain
Occurring in:
  1. DNA-binding transcriptional dual regulator CRP
IPR000595
Domain description: Cyclic nucleotide-binding domain
Occurring in:
  1. DNA-binding transcriptional dual regulator CRP
IPR018488
Domain description: Cyclic nucleotide-binding, conserved site
Occurring in:
  1. DNA-binding transcriptional dual regulator CRP
IPR018335
Domain description: Transcription regulator HTH, Crp-type, conserved site
Occurring in:
  1. DNA-binding transcriptional dual regulator CRP
IPR036390
Domain description: Winged helix DNA-binding domain superfamily
Occurring in:
  1. DNA-binding transcriptional dual regulator CRP
IPR036388
Domain description: Winged helix-like DNA-binding domain superfamily
Occurring in:
  1. DNA-binding transcriptional dual regulator CRP
IPR018490
Domain description: Cyclic nucleotide-binding domain superfamily
Occurring in:
  1. DNA-binding transcriptional dual regulator CRP
IPR014710
Domain description: RmlC-like jelly roll fold
Occurring in:
  1. DNA-binding transcriptional dual regulator CRP

Structure domains

CATH CATH domains
1.10.10.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Arc Repressor Mutant, subunit A
Homology: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Occurring in:
  1. DNA-binding transcriptional dual regulator CRP
The deposited structure of PDB entry 3rpq contains 2 copies of CATH domain 1.10.10.10 (Arc Repressor Mutant, subunit A) in DNA-binding transcriptional dual regulator CRP. Showing 1 copy in chain B.
2.60.120.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. DNA-binding transcriptional dual regulator CRP
The deposited structure of PDB entry 3rpq contains 2 copies of CATH domain 2.60.120.10 (Jelly Rolls) in DNA-binding transcriptional dual regulator CRP. Showing 1 copy in chain B.

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