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crystal structure of LGN/mInscuteable complex

X-ray diffraction
1.1Å resolution
PDB entry 3ro3 coloured by chain, front view.
PDB entry 3ro3 coloured by chain, side view.
PDB entry 3ro3 coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: G-protein-signaling modulator 2 and Protein inscuteable homolog
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Multimeric state: hetero dimer
Accessible surface area: 8807.21 Å2
Buried surface area: 2848.11 Å2
Dissociation area: 873.34 Å2
Dissociation energy (ΔGdiss): 6.13 kcal/mol
Dissociation entropy (TΔSdiss): 8.57 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-174560

Macromolecules

G-protein-signaling modulator 2
Chain: A
Length: 164 amino acids
Theoretical weight: 18.37 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8VDU0 (Residues: 198-357; Coverage: 24%)
Gene names: Gpsm2, Lgn, Pins
Pfam:
InterPro:
CATH: Tetratricopeptide repeat domain
G-protein-signaling modulator 2 in PDB entry 3ro3, assembly 1, front view.
G-protein-signaling modulator 2 in PDB entry 3ro3, assembly 1, side view.
G-protein-signaling modulator 2 in PDB entry 3ro3, assembly 1, top view.
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Protein inscuteable homolog
Chain: B
Length: 22 amino acids
Theoretical weight: 2.8 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q3HNM7 (Residues: 66-87; Coverage: 4%)
Gene name: Insc
Pfam: Inscuteable LGN-binding domain
InterPro:
Protein inscuteable homolog in PDB entry 3ro3, assembly 1, front view.
Protein inscuteable homolog in PDB entry 3ro3, assembly 1, side view.
Protein inscuteable homolog in PDB entry 3ro3, assembly 1, top view.
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