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CDK2 in complex with inhibitor L4-12

X-ray diffraction
1.85Å resolution
PDB 3rjc coloured by chain and viewed from the front.
PDB 3rjc coloured by chain and viewed from the side.
PDB 3rjc coloured by chain and viewed from the top.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 14400 Å2
Buried surface area: 700 Å2
Dissociation area: 350 Å2
Dissociation energy (ΔGdiss): -6 kcal/mol
Dissociation entropy (TΔSdiss): 4 kcal/mol
Interface energy (ΔGint): 2 kcal/mol
Symmetry number: 1

Macromolecules

Cyclin-dependent kinase 2
Chain: A
Length: 306 amino acids
Theoretical weight: 34.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Pfam: Protein kinase domain
InterPro:
CATH:
PDB 3rjc contains 1 copy of Cyclin-dependent kinase 2 in assembly 1. This protein is highlighted and viewed from the front.
PDB 3rjc contains 1 copy of Cyclin-dependent kinase 2 in assembly 1. This protein is highlighted and viewed from the side.
PDB 3rjc contains 1 copy of Cyclin-dependent kinase 2 in assembly 1. This protein is highlighted and viewed from the top.
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