› 3rc0

X-ray diffraction
2.19Å resolution

Human SETD6 in complex with RelA Lys310 peptide

Released:
DOI: 10.2210/pdb3rc0/pdb
PDB entry 3rc0 coloured by chain, front view.
PDB entry 3rc0 coloured by chain, side view.
PDB entry 3rc0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling.
Chang Y, Levy D, Horton JR, Peng J, Zhang X, Gozani O, Cheng X
Nucleic Acids Res 39 6380-9 (2011)
PMID: 21515635

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170004 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
N-lysine methyltransferase SETD6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 449 amino acids
Theoretical weight: 50.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TBK2 (Residues: 1-473; Coverage: 95%)
Gene name: SETD6
Sequence domains:
Structure domains:
Transcription factor p65 Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 15 amino acids
Theoretical weight: 1.91 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q04206 (Residues: 302-316; Coverage: 3%)
Gene names: NFKB3, RELA

Ligands and Environments

2 bound ligands:
Ligand EDO 16 x EDO
Ligand SAM 2 x SAM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P1
Unit cell:
a: 61.621Å b: 64.501Å c: 73.759Å
α: 78.73° β: 70.6° γ: 64.21°
R-values:
R R work R free
0.169 0.166 0.234
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

10 review citations

The Regulation of NF-κB Subunits by Phosphorylation.
Christian et al. (2016)
9 more

5 mentions without citation

Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives.
Andreoli et al. (2013)
4 more