3ra4

X-ray diffraction
2.7Å resolution

Structural studies of AAV8 capsid transitions associated with endosomal trafficking

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assemblies composition:
hetero 120-mer (preferred)
hetero dimer
hetero decamer
hetero dodecamer
hetero icosamer
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Capsid protein Chain: A
Molecule details ›
Chain: A
Length: 519 amino acids
Theoretical weight: 58.53 KDa
Source organism: Adeno-associated virus - 8
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8JQF8 (Residues: 220-738; Coverage: 70%)
Structure domains: Parvovirus coat protein VP1/VP2
DNA (5'-D(*CP*A)-3') Chain: D
Molecule details ›
Chain: D
Length: 2 nucleotides
Theoretical weight: 557 Da
Source organism: Aequorea victoria
Expression system: Homo sapiens

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P6322
Unit cell:
a: 257.94Å b: 257.94Å c: 448.69Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.212 0.212 0.213
Expression system: Homo sapiens