3r9a

X-ray diffraction
2.35Å resolution

Human alanine-glyoxylate aminotransferase in complex with the TPR domain of human PEX5P

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine--pyruvate aminotransferase Chains: A, C
Molecule details ›
Chains: A, C
Length: 394 amino acids
Theoretical weight: 43.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21549 (Residues: 1-392; Coverage: 100%)
Gene names: AGT1, AGXT, SPAT
Sequence domains: Aminotransferase class-V
Structure domains:
Peroxisomal targeting signal 1 receptor Chains: B, D
Molecule details ›
Chains: B, D
Length: 328 amino acids
Theoretical weight: 36.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P50542 (Residues: 315-639; Coverage: 51%)
Gene names: PEX5, PXR1
Sequence domains:
Structure domains: Tetratricopeptide repeat domain

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 59.367Å b: 99.156Å c: 127.698Å
α: 90° β: 96.66° γ: 90°
R-values:
R R work R free
0.187 0.184 0.239
Expression system: Escherichia coli