X-ray diffraction
1.95Å resolution

Crystal structure of human SOUL BH3 domain in complex with Bcl-xL


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2-like protein 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 156 amino acids
Theoretical weight: 17.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: Q07817 (Residues: 1-209; Coverage: 66%)
  • Best match: Q07817-2 (Residues: 1-125, 126-146)
Gene names: BCL2L, BCL2L1, BCLX
Sequence domains:
Heme-binding protein 2 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 26 amino acids
Theoretical weight: 2.97 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q9Y5Z4 (Residues: 147-172; Coverage: 13%)
Gene names: C6orf34, HEBP2, SOUL

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P43
Unit cell:
a: 66.83Å b: 66.83Å c: 175.22Å
α: 90° β: 90° γ: 90°
R R work R free
0.214 0.211 0.263
Expression systems:
  • Escherichia coli BL21
  • Not provided