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CDK2 in complex with inhibitor KVR-1-127

X-ray diffraction
1.8Å resolution
PDB entry 3r1s coloured by chain, front view.
PDB entry 3r1s coloured by chain, side view.
PDB entry 3r1s coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cyclin-dependent kinase 2
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Multimeric state: monomeric
Accessible surface area: 14612.19 Å2
Buried surface area: 191.72 Å2
Dissociation area: 95.86 Å2
Dissociation energy (ΔGdiss): -0.96 kcal/mol
Dissociation entropy (TΔSdiss): -0.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-150313

Macromolecules

Cyclin-dependent kinase 2
Chain: A
Length: 306 amino acids
Theoretical weight: 34.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Pfam: Protein kinase domain
InterPro:
CATH:
Cyclin-dependent kinase 2 in PDB entry 3r1s, assembly 1, front view.
Cyclin-dependent kinase 2 in PDB entry 3r1s, assembly 1, side view.
Cyclin-dependent kinase 2 in PDB entry 3r1s, assembly 1, top view.
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