Structure analysis

Crystal structure of MID domain from hAGO2 in complex with m7GpppG

X-ray diffraction
2.3Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: monomeric
Accessible surface area: 7500 Å2
Buried surface area: 650 Å2
Dissociation area: 350 Å2
Dissociation energy (ΔGdiss): 6 kcal/mol
Dissociation entropy (TΔSdiss): 7 kcal/mol
Interface energy (ΔGint): -9 kcal/mol
Symmetry number: 1
Assembly 2
Download    3D Visualisation
Multimeric state: monomeric
Accessible surface area: 7500 Å2
Buried surface area: 750 Å2
Dissociation area: 350 Å2
Dissociation energy (ΔGdiss): 3 kcal/mol
Dissociation entropy (TΔSdiss): 7 kcal/mol
Interface energy (ΔGint): -6 kcal/mol
Symmetry number: 1
Assembly 3
Download    3D Visualisation
Multimeric state: monomeric
Accessible surface area: 7300 Å2
Buried surface area: 650 Å2
Dissociation area: 300 Å2
Dissociation energy (ΔGdiss): 4 kcal/mol
Dissociation entropy (TΔSdiss): 7 kcal/mol
Interface energy (ΔGint): -7 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B, C
Length: 138 amino acids
Theoretical weight: 15.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UKV8 (Residues: 439-575; Coverage: 16%)
Gene names: AGO2, EIF2C2
InterPro:
CATH: Rossmann fold

Search similar proteins