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Crystal structure of Glucose-6-Phosphate Isomerase (PF14_0341) from Plasmodium falciparum 3D7

Source organism: Plasmodium falciparum 3D7
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

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EC 5.3.1.9: Glucose-6-phosphate isomerase

Reaction catalysed:
Alpha-D-glucose 6-phosphate = beta-D-fructofuranose 6-phosphate
Systematic name:
Alpha-D-glucose-6-phosphate aldose-ketose-isomerase (configuration-inverting)
Alternative Name(s):
  • D-glucose-6-phosphate ketol-isomerase
  • Glucose phosphate isomerase
  • Hexose monophosphate isomerase
  • Hexose phosphate isomerase
  • Hexosephosphate isomerase
  • Oxoisomerase
  • Phosphoglucoisomerase
  • Phosphoglucose isomerase
  • Phosphohexoisomerase
  • Phosphohexomutase
  • Phosphohexose isomerase
  • Phosphosaccharomutase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00342
Domain description: Phosphoglucose isomerase
Occurring in:
  1. Glucose-6-phosphate isomerase
The deposited structure of PDB entry 3qki contains 3 copies of Pfam domain PF00342 (Phosphoglucose isomerase) in Glucose-6-phosphate isomerase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001672
Domain description: Phosphoglucose isomerase (PGI)
Occurring in:
  1. Glucose-6-phosphate isomerase
IPR018189
Domain description: Phosphoglucose isomerase, conserved site
Occurring in:
  1. Glucose-6-phosphate isomerase
IPR023096
Domain description: Phosphoglucose isomerase, C-terminal
Occurring in:
  1. Glucose-6-phosphate isomerase
IPR035482
Domain description: Phosphoglucose isomerase, SIS domain 2
Occurring in:
  1. Glucose-6-phosphate isomerase
IPR035476
Domain description: Phosphoglucose isomerase, SIS domain 1
Occurring in:
  1. Glucose-6-phosphate isomerase
IPR046348
Domain description: SIS domain superfamily
Occurring in:
  1. Glucose-6-phosphate isomerase

Structure domains

CATH CATH domains
3.40.50.10490
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Glucose-6-phosphate isomerase like protein; domain 1
Occurring in:
  1. Glucose-6-phosphate isomerase
The deposited structure of PDB entry 3qki contains 6 copies of CATH domain 3.40.50.10490 (Rossmann fold) in Glucose-6-phosphate isomerase. Showing 2 copies in chain A.
1.10.1390.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Phosphoglucose isomerase, C-terminal domain
Homology: Phosphoglucose isomerase, C-terminal domain
Occurring in:
  1. Glucose-6-phosphate isomerase
The deposited structure of PDB entry 3qki contains 3 copies of CATH domain 1.10.1390.10 (Phosphoglucose isomerase, C-terminal domain) in Glucose-6-phosphate isomerase. Showing 1 copy in chain A.

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