3qbj

X-ray diffraction
2.21Å resolution

Crystal structure of dipeptidyl peptidase IV in complex with inhibitor

Released:
Source organism: Homo sapiens
Entry author: Liu SP

Function and Biology Details

Reaction catalysed:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dipeptidyl peptidase 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 748 amino acids
Theoretical weight: 86.56 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P27487 (Residues: 31-766; Coverage: 96%)
Gene names: ADCP2, CD26, DPP4
Sequence domains:
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 65.751Å b: 69.082Å c: 424.16Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.202 0.236
Expression system: Spodoptera frugiperda