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Crystal Structure of Human Flap Endonuclease FEN1 (D181A) in complex with substrate 5'-flap DNA and K+

X-ray diffraction
2.6Å resolution
PDB entry 3q8m coloured by chain, front view.
PDB entry 3q8m coloured by chain, side view.
PDB entry 3q8m coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule
3 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Flap endonuclease 1 and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 20535.8 Å2
Buried surface area: 5137.07 Å2
Dissociation area: 638.26 Å2
Dissociation energy (ΔGdiss): 9.15 kcal/mol
Dissociation entropy (TΔSdiss): 8.67 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-116748
Assembly 2
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Assembly Name: Flap endonuclease 1 and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 20535.28 Å2
Buried surface area: 5026.8 Å2
Dissociation area: 653.48 Å2
Dissociation energy (ΔGdiss): 6.1 kcal/mol
Dissociation entropy (TΔSdiss): 8.67 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-116748

Macromolecules

Flap endonuclease 1
Chains: A, B
Length: 341 amino acids
Theoretical weight: 38.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P39748 (Residues: 2-336; Coverage: 88%)
Gene names: FEN1, RAD2
Pfam:
InterPro:
CATH:
Flap endonuclease 1 in PDB entry 3q8m, assembly 1, front view.
Flap endonuclease 1 in PDB entry 3q8m, assembly 1, side view.
Flap endonuclease 1 in PDB entry 3q8m, assembly 1, top view.
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DNA chains D, G
Name: DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3')
Representative chains: D, G
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 18 nucleotides
Theoretical weight: 5.48 KDa
DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3') in PDB entry 3q8m, assembly 1, front view.
DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3') in PDB entry 3q8m, assembly 1, side view.
DNA (5'-D(*AP*CP*TP*CP*TP*GP*CP*CP*TP*CP*AP*AP*GP*AP*CP*GP*GP*T)-3') in PDB entry 3q8m, assembly 1, top view.
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DNA chains E, H
Name: DNA (5'-D(*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3')
Representative chains: E, H
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 12 nucleotides
Theoretical weight: 3.74 KDa
DNA (5'-D(*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3') in PDB entry 3q8m, assembly 1, front view.
DNA (5'-D(*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3') in PDB entry 3q8m, assembly 1, side view.
DNA (5'-D(*TP*TP*GP*AP*GP*GP*CP*AP*GP*AP*GP*T)-3') in PDB entry 3q8m, assembly 1, top view.
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DNA chains F, I
Name: DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3')
Representative chains: F, I
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 7 nucleotides
Theoretical weight: 2.06 KDa
DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3') in PDB entry 3q8m, assembly 1, front view.
DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3') in PDB entry 3q8m, assembly 1, side view.
DNA (5'-D(*AP*CP*CP*GP*TP*CP*C)-3') in PDB entry 3q8m, assembly 1, top view.
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