X-ray diffraction
2.1Å resolution

Crystal structure of the amino-terminal domain of HSP90 from Leishmania major, LMJF33.0312:M1-K213 in the presence of 17-DMAP-geldanamycin

Source organism: Leishmania major
Entry authors: Wernimont AK, Tempel W, Lin YH, Hutchinson A, MacKenzie F, Fairlamb A, Cossar D, Zhao Y, Schapira M, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Ferguson MAJ, Hui R, Pizarro JC, Hills T, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
HATPase_c domain-containing protein Chain: A

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: I41
Unit cell:
a: 111.73Å b: 111.73Å c: 48.98Å
α: 90° β: 90° γ: 90°
R R work R free
0.204 0.202 0.234
Expression system: Escherichia coli