Structure analysis

Crystal structure of the PUMILIO-homology domain from Human PUMILIO2 in complex with p38alpha NREa

X-ray diffraction
2Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct RNA molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 16800 Å2
Buried surface area: 2800 Å2
Dissociation area: 1,400 Å2
Dissociation energy (ΔGdiss): 1 kcal/mol
Dissociation entropy (TΔSdiss): 10 kcal/mol
Interface energy (ΔGint): 0 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 351 amino acids
Theoretical weight: 40.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8TB72 (Residues: 706-1056; Coverage: 33%)
Gene names: KIAA0235, PUM2, PUMH2
Pfam: Pumilio-family RNA binding repeat
InterPro:
CATH: Leucine-rich Repeat Variant

Search similar proteins

Name: 5'-R(UP*GP*UP*AP*AP*AP*UP*A)-3'
Representative chains: B
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 8 nucleotides
Theoretical weight: 2.54 KDa

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