Structure analysis

Crystal structure of the PUMILIO-homology domain from Human PUMILIO1 in complex with hunchback NRE

X-ray diffraction
2.6Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 1 distinct polypeptide molecule
1 distinct RNA molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero dimer
Accessible surface area: 16500 Å2
Buried surface area: 2700 Å2
Dissociation area: 1,300 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 10 kcal/mol
Interface energy (ΔGint): -7 kcal/mol
Symmetry number: 1
Assembly 2
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Multimeric state: hetero dimer

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: A, B
Length: 349 amino acids
Theoretical weight: 40.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q14671 (Residues: 828-1176; Coverage: 29%)
Gene names: KIAA0099, PUM1, PUMH1
Pfam: Pumilio-family RNA binding repeat
InterPro:
CATH: Leucine-rich Repeat Variant

Search similar proteins

Name: 5'-R(UP*GP*UP*AP*UP*AP*UP*A)-3'
Representative chains: C, D
Source organism: Homo sapiens [9606]
Expression system: Not provided
Length: 8 nucleotides
Theoretical weight: 2.51 KDa

Search similar RNA